What Are PGT-A Results?
PGT-A (preimplantation genetic testing for aneuploidy) is a test performed on embryos created through IVF. It checks for the correct number of chromosomes. Embryos with the expected number are often called euploid, while those with extra or missing chromosomes are aneuploid. Your clinic will provide a report that classifies each embryo based on the testing laboratory’s criteria.
It’s important to understand that PGT-A is a screening tool, not a guarantee of pregnancy or a healthy baby. It helps your medical team choose which embryos to consider for transfer, but many factors influence the outcome.
What Is Mosaicism?
Mosaicism means that an embryo has a mixture of cells: some with the normal number of chromosomes and some with an abnormal number. This is different from a uniformly abnormal embryo. Mosaicism is reported as a percentage, for example, 20% or 40%, indicating the proportion of abnormal cells detected in the biopsy sample.
Mosaic embryos are often categorized as low, medium, or high level, depending on the percentage. However, there is no universal standard for these categories, so it’s essential to ask your clinic how they interpret the results.
How Are Mosaic Embryos Reported?
PGT-A reports typically list each embryo with a result such as euploid, aneuploid, or mosaic. For mosaic embryos, the report may include the specific chromosome involved and the percentage of abnormal cells. Some reports also note whether the abnormality is a gain or loss of a chromosome.
Because testing methods and laboratory criteria vary, the same embryo might be classified differently by different labs. Always ask your clinic to explain the report in detail, including what the numbers mean for your specific situation.
What Does a Mosaic Result Mean for Transfer?
Mosaic embryos can sometimes lead to a healthy pregnancy, but the outcome is uncertain. Some studies suggest that embryos with lower levels of mosaicism may have a better chance than those with higher levels, but this is not guaranteed. Your clinic will consider the specific mosaic pattern, your medical history, and other factors when advising you.
It’s crucial to have a detailed discussion with your fertility specialist about the risks and benefits of transferring a mosaic embryo. They can help you weigh the options based on your individual circumstances.
Questions to Ask Your Clinic About Mosaic Results
- What is the exact percentage of mosaicism for my embryo?
- Which chromosome is affected, and does that matter?
- How does your lab categorize low, medium, or high mosaicism?
- What are the potential risks if I transfer a mosaic embryo?
- Are there any additional tests or counseling available?
- What is your clinic’s policy on mosaic embryo transfer?
Next Steps After Receiving PGT-A Results
- Review the report with your fertility specialist.
- Ask for a clear explanation of each embryo’s status.
- Discuss the options for transfer, further testing, or additional IVF cycles.
- Consider genetic counseling to understand the implications.
- Take time to make an informed decision that aligns with your values and goals.
Understanding the Limitations of PGT-A
PGT-A is a powerful tool, but it has limitations. It cannot detect all genetic conditions, and it does not guarantee a successful pregnancy. The test is performed on a few cells from the embryo, which may not represent the entire embryo. Additionally, mosaicism can be an artifact of the testing process.
It’s also important to note that PGT-A is not recommended for everyone. Your clinic will advise whether it is appropriate for your situation based on factors like age and medical history.
Seeking Support and Information
Receiving mosaic results can be confusing and emotional. It’s okay to seek a second opinion or ask for more time to decide. Many clinics in Thailand offer counseling services to help you navigate this process.
For more general information about PGT in Thailand, you can visit our PGT in Thailand page. You may also find our guides and FAQ sections helpful.
Frequently asked questions
What is the difference between a mosaic and an aneuploid embryo?
A mosaic embryo has a mixture of normal and abnormal cells, while an aneuploid embryo has all cells with an abnormal number of chromosomes. Mosaic embryos may have a chance to develop normally, but the outcome is uncertain.
Can a mosaic embryo result in a healthy baby?
In some cases, mosaic embryos have led to healthy live births, but the risk of abnormalities is higher than with euploid embryos. The outcome depends on the specific mosaic pattern and other factors. Your clinic can provide more personalized guidance.
How is mosaicism percentage determined?
The percentage is estimated from the biopsy sample, which contains a few cells from the embryo. The laboratory analyzes the proportion of abnormal cells in that sample. This may not reflect the entire embryo.
Should I consider transferring a mosaic embryo?
The decision to transfer a mosaic embryo is complex and should be made in consultation with your fertility specialist and genetic counselor. They will consider the level of mosaicism, the specific chromosome involved, and your medical history.
Are there additional tests to confirm mosaicism?
Sometimes, further testing such as re-biopsy or comprehensive chromosome screening may be offered, but this is not always possible or conclusive. Your clinic can discuss the options available.
Continue your research
Medical information notice: This article is educational and does not replace individual assessment, diagnosis, genetic counselling or treatment advice from a licensed clinician. Provider services, availability, fees and policies should be verified directly before booking.